The story finds Jason Mewes' Jay and Smith's Silent Bob learning that a studio wants to reboot the Bluntman And Chronic movie that was based on the comic inspired by the two stoners. And they're not happy. Again. So begins a cross-
年轻女孩贝丝·斯洛克姆（奥布瑞·普拉扎 Aubrey Plaza 饰）在野外散心的时候被毒蛇咬中，毒发身亡。这一事件令贝丝的男友扎克（戴恩·德哈恩 Dane DeHaan 饰）痛不欲生，久久无法从悲伤中解脱出来。某天，当他一早前去斯洛克姆家时，竟惊讶地瞥见了贝丝的身影。贝丝的爸爸莫里（约翰·C·赖利 John C. Reilly 饰）百般遮掩，却没法阻挡被爱情折磨的几近疯狂的扎克。一度生离死别的两个有情人再次见面，他们之间的情意更浓，如胶似漆。可是随着时间的流逝，贝丝的身上却出现种种异样，她皮肤苍白溃烂，
